App/Forwarding Profile suggestions for slow mobile 5G hotspot connections

We have a few users that use mobile 5G hotspots in rural US areas for Internet access that have complained about slow ZIA/ZPA performance. I’m just looking for any suggested changes I could make to their App/Forwarding profile (or any other ZIA/ZPA changes) to make the best of these slow Internet connections. Our default configuration uses Tunnel 2.0 with no PAC file.

Without knowing more have you looked at lowering the MTU in the Tunnel 2.0 settings: